Why we would want to get rid of x86-64? FPU side already has basically no x86 (x87) stuff because x86-64 compilers only create SSE2 or higher FPU code (x87 will work but compilers never created such code). Only major problem is "only" 16 GP and FPU registers but it can be solved with new instruction set.
Only integer side still uses x86-based instructions but again, it too can be solved with new instruction set that will some time replace x86-64.
it's a messy, complex, instruction set with lots of side cases and oddities. If you get away from Windows (well, even they are looking at ARM now but...), Linux distros give you 90% of your software on even the fringe platforms like Alpha, PA-RISC, when the had Itanium distros, etc. that they support. And it's closer to 98-99% software coverage on ARM and probably on MIPS (that's not counting running things under emulation, which x86/x86-64 emulation on ARM is quite good now.)
I'm running a Coffee Lake desktop, Tiger Lake notebook, and had a Ryzen 3450U notebook before that; it's all x86-64. But I'd be missing out on nothing if it was an ARM, I could run steam and wine games in x86/x86-64 emulation and get plenty of performance, with literally eveyrthing else being native.
But I had an Acer Chromebook 13 with a Tegra K1 (quad-core ARM + 1 "little" core for the BIG.little setup; and a roughlty GTX650-equivalent GPU), I threw Chrubuntu on there and that thing got 22 hours battery life under real use; 12 hours if I ran video encoded and whatever and kept the cores at 100% load. It ran a full Linux desktop VERY well, the video encodes were fast (I had a Sandy Bridge desktop at that point and the Chromebook cleaned it's clock). I'd LOVE to get an ARM notebook for my next one! The GPU "could" be a weak point, but apparently the Qualcomm GPUs are direct descendents of the whatever mobile Radeon was in development when ATI sold to AMD, and have excellent driver support in Linux (Mesa Gallium's "Ardreno" driver, Ardreno is a anagram for Radeon..) and apparently quite good in ARM Windows too.)
If I have a desktop, I'd have lower power consumption, quieter, and less heat production. Same in a notebook but that also gives you the benefit of massive battery life increase.
(Side note: A few vendors make ARM workstations. So someone asked "This chip you're using, the GPU is not very strong. What do you do about that?" "It's a workstation, it has PCIe slots, we threw a 4090 in it." Maybe Windows doesn't have them yet, but Linux Mesa Gllium drivers cover AMD and Intel (kind of perverse to have and ARM CPU with Intel GPU but someone tried it and it worked!), and Nvidia has had Linux ARM drivers for many years. If Windows for ARM doesn't, the Linux and Windows Nvidia drivers are reportedly like the same core with just an OS-specific wrapper, so presumably they are most of the way there toward gettinga Nvidia Windows ARM driver if they wanted to.)